The Dennehy Lab receives funding from NIH for proposal “Novel Strategies for Treating Biofilm-Forming Pathogens with Phage Therapy”
This project is a collaboration with Dr. Fabrizio Spagnolo. The aim of the proposed work is to assess the viability of a multi-pronged phage therapy approach to eliminate biofilm-associated bacteria. Specifically, we propose to induce prophages already contained within biofilm-associated bacteria to disrupt biofilms. Simultaneously, lytic phages will be applied to kill bacteria dispersing from the biofilm at the point of exit. This dual strategy may allow the eradication of intransigent infections resistant to traditional antibacterial therapy.